Full product name
Rap guanine nucleotide exchange factor 6
Code
BT-AP13916
Host
Rabbit
Isotype
IgG
Size
100ul,50ul,20ul
Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human protein . at AA range: 460-540
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Contains 1 cyclic nucleotide-binding domain.,Contains 1 N-terminal Ras-GEF domain.,Contains 1 PDZ (DHR) domain.,Contains 1 Ras-associating domain.,Contains 1 Ras-GEF domain.,subcellular location:Upon binding to M-Ras, it translocates to the plasma membrane.,subunit:Interacts with the second PDZ domain of human PTP1e.,tissue specificity:Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.,
Uniprot accession
Gene ID
Human: 51735
Synonyms
Rap guanine nucleotide exchange factor 6 ;PDZ domain-containing guanine nucleotide exchange factor 2;PDZ-GEF2;RA-GEF-2
Research area
Epigenetics and nuclear signaling
Target protein
RAPGEF6
