Full product name
Serine/threonine-protein kinase SIK1
Code
BT-AP14226
Host
Rabbit
Isotype
IgG
Size
20ul,50ul,100ul
Clonality
Polyclonal
Immunogen
Synthesized peptide derived from human protein . at AA range: 130-210
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39.,Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily.,Contains 1 protein kinase domain.,Contains 1 UBA domain.,subcellular location:Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ.,subunit:Binds to and is activated by YWHAZ when phosphorylated on Thr-182.,
Uniprot accession
Gene ID
Human: 150094
Synonyms
Serine/threonine-protein kinase SIK1 ;EC 2.7.11.1;Salt-inducible kinase 1;SIK-1;Serine/threonine-protein kinase SNF1-like kinase 1;Serine/threonine-protein kinase SNF1LK
Research area
Cardiovascular; Cell biology; Epigenetics and nuclear signaling; Signal transduction
Target protein
SIK1
