Full product name
Signal transducer and activator of transcription 3
Code
BT-AP14538
Host
Rabbit
Isotype
IgG
Size
20ul,50ul,100ul
Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human STAT3. AA range:656-705
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper
Uniprot accession
Molecular weight
88068
Gene ID
Human: 6774; Mouse: 20848; Rat: 25125
Synonyms
Signal transducer and activator of transcription 3; STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor
Research area
Epigenetics and nuclear signaling; Cancer; Signal transduction; Microbiology; Stem cells; Cardiovascular; Developmental biology
Target protein
STAT3
