Full product name
Tankyrase-1
Code
BT-AP15047
Host
Rabbit
Isotype
IgG
Size
100ul,50ul,20ul
Clonality
Polyclonal
Immunogen
Synthesized peptide derived from part region of human protein
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
Catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length.,PTM:ADP-ribosylated (-auto).,PTM:Phosphorylated on serine residues by MAPK kinases upon insulin stimulation.,Contains 1 PARP catalytic domain.,Contains 1 SAM (sterile alpha motif) domain.,Contains 15 ANK repeats.,subcellular location:Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1.,subunit:Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2.,tissue specificity:Ubiquitous; highest levels in testis.,
Uniprot accession
Gene ID
Human: 8658
Synonyms
Tankyrase-1 ;TANK1;EC 2.4.2.30;ADP-ribosyltransferase diphtheria toxin-like 5;ARTD5;Poly [ADP-ribose] polymerase 5A;TNKS-1;TRF1-interacting ankyrin-related ADP-ribose polymerase;Tankyras
Research area
Epigenetics and nuclear signaling
Target protein
TNKS
