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Product > Antibody > CSNK2A2 Monoclonal Antibody
CSNK2A2 Monoclonal Antibody
CSNK2A2 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 1E1
Host: Mouse
Reactivity:Human, Mouse
Applications: WB,FCM
Product Summary
Size:
50μL
Clonality: 1E1
Host: Mouse
Reactivity: Human,Mouse
Applications: WB,FCM
Product overview
Code
BT-MCA3570
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
1E1
Immunogen
Purified recombinant fragment of human CSNK2A2 (AA: 194-350) expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.
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