BT-MCA2963

Mouse

Mouse IgG1

100μL,50μL

Monoclonal

Purified recombinant fragment of human PTPN11 (AA: 263-329) expressed in E. Coli.

Purified antibody in PBS with 0.05% sodium azide

Store at 4°C short term. Aliquot and store at -20°C long term.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.

Q06124:;

68.4kDa

5781

CFC;NS1;SHP2;BPTP3;PTP2C;PTP-1D;SH-PTP2;SH-PTP3;MGC14433

Signal Transduction

PTPN11