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Product > Antibody > HAS2 Monoclonal Antibody
HAS2 Monoclonal Antibody
HAS2 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 4E7
Host: Mouse
Reactivity:Human
Applications: WB,IHC,ICC
Product Summary
Size:
50μL
Clonality: 4E7
Host: Mouse
Reactivity: Human
Applications: WB,IHC,ICC
Product overview
Code
BT-MCA2439
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
4E7
Immunogen
Purified recombinant fragment of human HAS2 (AA: 67-170) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
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