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Product > Antibody > CYP3A4 Monoclonal Antibody
CYP3A4 Monoclonal Antibody
CYP3A4 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 3H8
Host: Mouse
Reactivity:Human
Applications: IHC,ICC,FCM
Product Summary
Size:
50μL
Clonality: 3H8
Host: Mouse
Reactivity: Human
Applications: IHC,ICC,FCM
Product overview
Code
BT-MCA4652
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
3H8
Immunogen
Purified recombinant fragment of human CYP3A4 expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.
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