We use cookies to give you the best experience. By using bt-laboratory.com, you
consent to our use of cookies. If you do not wish to receive our cookies, adjust your browser settings. Read
our Cookies
Policy to learn more.
Reject All
Accept All Cookies
We use cookies to give you the best experience. By using bt-laboratory.com,
you consent to our use of cookies. If you do not wish to receive our cookies, adjust your browser settings.
Read our Cookies
Policy to learn more.
Home >
Product > Antibody > PPM1A Monoclonal Antibody
PPM1A Monoclonal Antibody
PPM1A Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 7F12H6
Host: Mouse
Reactivity:Human, Monkey
Applications: WB,FCM
Product Summary
Size:
50μL
Clonality: 7F12H6
Host: Mouse
Reactivity: Human,Monkey
Applications: WB,FCM
Product overview
Code
BT-MCA2944
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
7F12H6
Immunogen
Purified recombinant fragment of human PPM1A (AA: 202-382) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
We are continuously updating our Antibody catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.