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Product > Antibody > DCX Monoclonal Antibody
DCX Monoclonal Antibody
DCX Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 2G5
Host: Mouse
Reactivity:Human
Applications: WB,IHC,ICC,FCM
Product Summary
Size:
50μL
Clonality: 2G5
Host: Mouse
Reactivity: Human
Applications: WB,IHC,ICC,FCM
Product overview
Code
BT-MCA3581
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
2G5
Immunogen
Purified recombinant fragment of human DCX (AA: 362-411) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
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