Code
BT-MCA3693
Host
Mouse
Isotype
Mouse IgG1
Size
100μL,50μL
Clonality
Monoclonal
Immunogen
Purified recombinant fragment of human TGFb1 (AA: 62-195) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease
Uniprot accession
Molecular weight
44.3kDa
Gene ID
7040
Synonyms
CED;LAP;DPD1;TGFB;TGFbeta
Research area
Signal transduction,Cancer,Metabolism,Stem cells,Cardiovascular
Target protein
TGFb1
