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Product > Antibody > E2F1 Monoclonal Antibody
E2F1 Monoclonal Antibody
E2F1 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 8G9
Host: Mouse
Reactivity:Human, Mouse
Applications: WB,IHC,FCM
Product Summary
Size:
50μL
Clonality: 8G9
Host: Mouse
Reactivity: Human,Mouse
Applications: WB,IHC,FCM
Product overview
Code
BT-MCA4272
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
8G9
Immunogen
Purified recombinant fragment of human E2F1 (AA: 69-223) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
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