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Product > Antibody > VAV1 Monoclonal Antibody
VAV1 Monoclonal Antibody
VAV1 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 2E11
Host: Mouse
Reactivity:Human
Applications: WB,FCM
Product Summary
Size:
50μL
Clonality: 2E11
Host: Mouse
Reactivity: Human
Applications: WB,FCM
Product overview
Code
BT-MCA2621
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
2E11
Immunogen
Purified recombinant fragment of human VAV1 (AA: 121-324) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
We are continuously updating our Antibody catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.
