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Product > Antibody > RAF1 Monoclonal Antibody
RAF1 Monoclonal Antibody
RAF1 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 4G4
Host: Mouse
Reactivity:Human
Applications: WB,IHC,FCM
Product Summary
Size:
50μL
Clonality: 4G4
Host: Mouse
Reactivity: Human
Applications: WB,IHC,FCM
Product overview
Code
BT-MCA2994
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
4G4
Immunogen
Purified recombinant fragment of human RAF1 expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
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