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Product > Antibody > FAS Monoclonal Antibody
FAS Monoclonal Antibody
FAS Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 4F8H6
Host: Mouse
Reactivity:Human
Applications: WB,ICC,FCM
Product Summary
Size:
50μL
Clonality: 4F8H6
Host: Mouse
Reactivity: Human
Applications: WB,ICC,FCM
Product overview
Code
BT-MCA2693
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
4F8H6
Immunogen
Purified recombinant fragment of human FAS expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
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