We use cookies to give you the best experience. By using bt-laboratory.com, you
consent to our use of cookies. If you do not wish to receive our cookies, adjust your browser settings. Read
our Cookies
Policy to learn more.
Reject All
Accept All Cookies
We use cookies to give you the best experience. By using bt-laboratory.com,
you consent to our use of cookies. If you do not wish to receive our cookies, adjust your browser settings.
Read our Cookies
Policy to learn more.
Home >
Product > Antibody > ALPL Monoclonal Antibody
ALPL Monoclonal Antibody
ALPL Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 2F4
Host: Mouse
Reactivity:Human
Applications: WB,IHC,FCM
Product Summary
Size:
50μL
Clonality: 2F4
Host: Mouse
Reactivity: Human
Applications: WB,IHC,FCM
Product overview
Code
BT-MCA3985
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
2F4
Immunogen
Purified recombinant fragment of human ALPL expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
We are continuously updating our Antibody catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.