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Product > Antibody > LMNA Monoclonal Antibody
LMNA Monoclonal Antibody
LMNA Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 4E7
Host: Mouse
Reactivity:Human, Mouse, Rat
Applications: WB,IHC
Product Summary
Size:
50μL
Clonality: 4E7
Host: Mouse
Reactivity: Human,Mouse,Rat
Applications: WB,IHC
Product overview
Code
BT-MCA4638
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
4E7
Immunogen
Purified recombinant fragment of human LMNA expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
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