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Product > Antibody > MSH6 Monoclonal Antibody
MSH6 Monoclonal Antibody
MSH6 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 5B11
Host: Mouse
Reactivity:Human
Applications: WB
Product Summary
Size:
50μL
Clonality: 5B11
Host: Mouse
Reactivity: Human
Applications: WB
Product overview
Code
BT-MCA4583
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
5B11
Immunogen
Purified recombinant fragment of human MSH6 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.
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