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Product > Antibody > BMI1 Monoclonal Antibody
BMI1 Monoclonal Antibody
BMI1 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 3E3
Host: Mouse
Reactivity:Human
Applications: IHC,ICC,FCM
Product Summary
Size:
50μL
Clonality: 3E3
Host: Mouse
Reactivity: Human
Applications: IHC,ICC,FCM
Product overview
Code
BT-MCA2235
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
3E3
Immunogen
Purified recombinant fragment of human BMI1 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
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