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Product > Antibody > MBP Monoclonal Antibody
MBP Monoclonal Antibody
MBP Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 2H9
Host: Mouse
Reactivity:Human
Applications: IHC,ICC,FCM
Product Summary
Size:
50μL
Clonality: 2H9
Host: Mouse
Reactivity: Human
Applications: IHC,ICC,FCM
Product overview
Code
BT-MCA4629
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
2H9
Immunogen
Purified recombinant fragment of human MBP expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
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