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Home >
Product > Antibody > ApoB Monoclonal Antibody
ApoB Monoclonal Antibody
ApoB Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 6G6
Host: Mouse
Reactivity:Human
Applications: ICC,FCM
Product Summary
Size:
50μL
Clonality: 6G6
Host: Mouse
Reactivity: Human
Applications: ICC,FCM
Product overview
Code
BT-MCA2319
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
6G6
Immunogen
Purified recombinant fragment of human ApoB expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
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