Code
BT-MCA2496
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
3G8
Immunogen
Purified recombinant fragment of human ABCG2 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue.Tissue specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon.
Uniprot accession
Molecular weight
72kDa
Gene ID
9429
Synonyms
MRX;MXR;ABCP;BCRP;BMDP;MXR1;ABC15;BCRP1;CD338;CDw338;EST157481;MGC102821
Research area
Tags & cell markers,Signal transduction,Stem cells,Cancer,Metabolism
Target protein
ABCG2
