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Home >
Product > Antibody > AIF Monoclonal Antibody
AIF Monoclonal Antibody
AIF Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 4E7
Host: Mouse
Reactivity:Human, Mouse, Monkey, Rat
Applications: WB,IHC,ICC,FCM
Product Summary
Size:
50μL
Clonality: 4E7
Host: Mouse
Reactivity: Human,Mouse,Monkey,Rat
Applications: WB,IHC,ICC,FCM
Product overview
Code
BT-MCA2541
Host
Mouse
Isotype
Mouse IgG2b
Size
50μL
Clonality
4E7
Immunogen
Purified recombinant fragment of human AIF expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10
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