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Product > Antibody > BMPR2 Monoclonal Antibody
BMPR2 Monoclonal Antibody
BMPR2 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 1F12
Host: Mouse
Reactivity:Human, Mouse, Rat, Monkey
Applications: WB,IHC
Product Summary
Size:
50μL
Clonality: 1F12
Host: Mouse
Reactivity: Human,Mouse,Rat,Monkey
Applications: WB,IHC
Product overview
Code
BT-MCA2073
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
1F12
Immunogen
Purified recombinant fragment of human BMPR2 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. (provided by RefSeq)
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