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Product > Antibody > CD276 Monoclonal Antibody
CD276 Monoclonal Antibody
CD276 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 6A1
Host: Mouse
Reactivity:Human
Applications: IHC,FCM
Product Summary
Size:
50μL
Clonality: 6A1
Host: Mouse
Reactivity: Human
Applications: IHC,FCM
Product overview
Code
BT-MCA4390
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
6A1
Immunogen
Purified recombinant fragment of human CD276 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Costimulatory B7 molecules (e.g., B7-1, or CD80; MIM 112203) signal through CD28 (MIM 186760) family molecules such as CD28, CTLA4 (MIM 123890), and ICOS (MIM 604558). May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
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