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Product > Antibody > CDH1 Monoclonal Antibody
CDH1 Monoclonal Antibody
CDH1 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 7A2
Host: Mouse
Reactivity:Human, Mouse, Monkey
Applications: WB
Product Summary
Size:
50μL
Clonality: 7A2
Host: Mouse
Reactivity: Human,Mouse,Monkey
Applications: WB
Product overview
Code
BT-MCA2220
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
7A2
Immunogen
Purified recombinant fragment of human CDH1 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
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