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Product > Antibody > KDM3A Monoclonal Antibody
KDM3A Monoclonal Antibody
KDM3A Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 1E12
Host: Mouse
Reactivity:Human
Applications: WB,IHC
Product Summary
Size:
50μL
Clonality: 1E12
Host: Mouse
Reactivity: Human
Applications: WB,IHC
Product overview
Code
BT-MCA3747
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
1E12
Immunogen
Purified recombinant fragment of human KDM3A expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and alpha-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.
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