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Product > Antibody > FOXD3 Monoclonal Antibody
FOXD3 Monoclonal Antibody
FOXD3 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 5G9
Host: Mouse
Reactivity:Human, Mouse, Monkey
Applications: WB,IHC
Product Summary
Size:
50μL
Clonality: 5G9
Host: Mouse
Reactivity: Human,Mouse,Monkey
Applications: WB,IHC
Product overview
Code
BT-MCA2153
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
5G9
Immunogen
Purified recombinant fragment of human FOXD3 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation. FoxD3 is required for the maintenance of the mammalian neural crest; FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures. FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.
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