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Product > Antibody > SMAD4 Monoclonal Antibody
SMAD4 Monoclonal Antibody
SMAD4 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 4G1C6
Host: Mouse
Reactivity:Human, Mouse
Applications: WB,IHC,ICC,FCM
Product Summary
Size:
50μL
Clonality: 4G1C6
Host: Mouse
Reactivity: Human,Mouse
Applications: WB,IHC,ICC,FCM
Product overview
Code
BT-MCA2271
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
4G1C6
Immunogen
Purified recombinant fragment of human SMAD4 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Common mediator of signal transduction by TGF-beta (transforming growth factor) superfamily; SMAD4 is the common SMAD (co-SMAD). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. May act as a tumor suppressor. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
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