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Product > Antibody > ATP2C1 Monoclonal Antibody
ATP2C1 Monoclonal Antibody
ATP2C1 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 4G12
Host: Mouse
Reactivity:Human, Monkey
Applications: WB,IHC
Product Summary
Size:
50μL
Clonality: 4G12
Host: Mouse
Reactivity: Human,Monkey
Applications: WB,IHC
Product overview
Code
BT-MCA2532
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
4G12
Immunogen
Purified recombinant fragment of ATP2C1 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco(endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
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