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Product > Antibody > RAG2 Monoclonal Antibody
RAG2 Monoclonal Antibody
RAG2 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 4D5
Host: Mouse
Reactivity:Human
Applications:
Product Summary
Size:
50μL
Clonality: 4D5
Host: Mouse
Reactivity: Human
Applications:
Product overview
Code
BT-MCA3435
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
4D5
Immunogen
Purified recombinant fragment of human RAG2(350-527aa) expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.
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