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Product > Antibody > CDKN1B Monoclonal Antibody
CDKN1B Monoclonal Antibody
CDKN1B Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 3D8
Host: Mouse
Reactivity:Human
Applications:
Product Summary
Size:
50μL
Clonality: 3D8
Host: Mouse
Reactivity: Human
Applications:
Product overview
Code
BT-MCA3324
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
3D8
Immunogen
Purified recombinant fragment of human CDKN1B expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. Decreased levels of p27Kip1, mainly due to proteosomal degradation, are found in various epithelial tumors originating from lung, breast, colon, ovary, esophagus, thyroid and prostate.Tissue specificity: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney.
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