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Product > Antibody > DAXX Monoclonal Antibody
DAXX Monoclonal Antibody
DAXX Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 7A11
Host: Mouse
Reactivity:Human
Applications: WB,ICC,FCM
Product Summary
Size:
50μL
Clonality: 7A11
Host: Mouse
Reactivity: Human
Applications: WB,ICC,FCM
Product overview
Code
BT-MCA4452
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
7A11
Immunogen
Purified recombinant fragment of human DAXX expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
DAXX (death-domain associated protein), it is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.
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