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Product > Antibody > PGA5 Monoclonal Antibody
PGA5 Monoclonal Antibody
PGA5 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 2C1
Host: Mouse
Reactivity:Human
Applications: WB,IHC
Product Summary
Size:
50μL
Clonality: 2C1
Host: Mouse
Reactivity: Human
Applications: WB,IHC
Product overview
Code
BT-MCA4580
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
2C1
Immunogen
Purified recombinant fragment of human PGA5 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. PGA5 is inhibited by ovUS-1, a uterine serpin.
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