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Home >
Product > Antibody > PTEN Monoclonal Antibody
PTEN Monoclonal Antibody
PTEN Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 1B8
Host: Mouse
Reactivity:Human, Mouse
Applications: WB,ICC,FCM
Product Summary
Size:
50μL
Clonality: 1B8
Host: Mouse
Reactivity: Human,Mouse
Applications: WB,ICC,FCM
Product overview
Code
BT-MCA4500
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
1B8
Immunogen
Purified recombinant fragment of PTEN expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
We are continuously updating our Antibody catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.
