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Product > Antibody > NGFR Monoclonal Antibody
NGFR Monoclonal Antibody
NGFR Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 2F1C2
Host: Mouse
Reactivity:Human
Applications: ICC,FCM
Product Summary
Size:
50μL
Clonality: 2F1C2
Host: Mouse
Reactivity: Human
Applications: ICC,FCM
Product overview
Code
BT-MCA4553
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
2F1C2
Immunogen
Purified recombinant fragment of human NGFR expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).
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