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Product > Antibody > FAK Monoclonal Antibody
FAK Monoclonal Antibody
FAK Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 10H7
Host: Mouse
Reactivity:Human, Mouse
Applications: WB,IHC,ICC
Product Summary
Size:
50μL
Clonality: 10H7
Host: Mouse
Reactivity: Human,Mouse
Applications: WB,IHC,ICC
Product overview
Code
BT-MCA3365
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
10H7
Immunogen
Purified recombinant fragment of human FAK expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. Tissue specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.RD: Focal adhesion kinase 1 (FAK) is a ubiquitously expressed non-receptor protein tyrosine kinase that is concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. This cellular localization is directed by a
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