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Product > Antibody > MUSK Monoclonal Antibody
MUSK Monoclonal Antibody
MUSK Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 10A4
Host: Mouse
Reactivity:Human
Applications: IHC,ICC
Product Summary
Size:
50μL
Clonality: 10A4
Host: Mouse
Reactivity: Human
Applications: IHC,ICC
Product overview
Code
BT-MCA4420
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
10A4
Immunogen
Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.
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