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Product > Antibody > GATA4 Monoclonal Antibody
GATA4 Monoclonal Antibody
GATA4 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 6H10
Host: Mouse
Reactivity:Human, Rat
Applications: WB
Product Summary
Size:
50μL
Clonality: 6H10
Host: Mouse
Reactivity: Human,Rat
Applications: WB
Product overview
Code
BT-MCA2110
Host
Mouse
Isotype
Mouse IgG2b
Size
50μL
Clonality
6H10
Immunogen
Purified recombinant fragment of human GATA4 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
GATA binding protein 4, also known as GATA4, it is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.
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