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Product > Antibody > WNT1 Monoclonal Antibody
WNT1 Monoclonal Antibody
WNT1 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 10C8
Host: Mouse
Reactivity:Human, Mouse
Applications: WB,IHC,ICC,FCM
Product Summary
Size:
50μL
Clonality: 10C8
Host: Mouse
Reactivity: Human,Mouse
Applications: WB,IHC,ICC,FCM
Product overview
Code
BT-MCA2624
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
10C8
Immunogen
Purified recombinant fragment of WNT1 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
WNT1: wingless-type MMTV integration site family, member 1. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant rolein Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.
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