BT-MCA2968

Mouse

Mouse IgG1

50μL

5E9B2

Purified recombinant fragment of F8 expressed in E. Coli.

Ascitic fluid containing 0.03% sodium azide.

Store at 4°C short term. Aliquot and store at -20°C long term.

F8: coagulation factor VIII, procoagulant component. This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

P00451: ;

2157

AHF;F8B;F8C;HEMA;FVIII

Cardiovascular

F8