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Home >
Product > Antibody > FES Monoclonal Antibody
FES Monoclonal Antibody
FES Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 5A11G5
Host: Mouse
Reactivity:Human
Applications:
Product Summary
Size:
50μL
Clonality: 5A11G5
Host: Mouse
Reactivity: Human
Applications:
Product overview
Code
BT-MCA4346
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
5A11G5
Immunogen
Purified recombinant fragment of FES expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.
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