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Product > Antibody > SORL1 Monoclonal Antibody
SORL1 Monoclonal Antibody
SORL1 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 3B6B11
Host: Mouse
Reactivity:Human
Applications: IHC,ICC
Product Summary
Size:
50μL
Clonality: 3B6B11
Host: Mouse
Reactivity: Human
Applications: IHC,ICC
Product overview
Code
BT-MCA2474
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
3B6B11
Immunogen
Purified recombinant fragment of human SORL1 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.
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