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Product > Antibody > DDR2 Monoclonal Antibody
DDR2 Monoclonal Antibody
DDR2 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 3B11E4
Host: Mouse
Reactivity:Human
Applications: IHC,ICC
Product Summary
Size:
50μL
Clonality: 3B11E4
Host: Mouse
Reactivity: Human
Applications: IHC,ICC
Product overview
Code
BT-MCA3721
Host
Mouse
Isotype
Mouse IgG2a
Size
50μL
Clonality
3B11E4
Immunogen
Purified recombinant fragment of human DDR2 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.
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