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Product > Antibody > FER Monoclonal Antibody
FER Monoclonal Antibody
FER Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 5D2C4
Host: Mouse
Reactivity:Human, Mouse
Applications: WB,IHC,ICC
Product Summary
Size:
50μL
Clonality: 5D2C4
Host: Mouse
Reactivity: Human,Mouse
Applications: WB,IHC,ICC
Product overview
Code
BT-MCA4151
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
5D2C4
Immunogen
Purified recombinant fragment of human FER expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
FER (fer tyrosine kinase) is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases, which shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The Fes /Fps family is distinct from c-Src, c-Abl and related nRTKs and was originally distinguished as a homolog to retroviral oncoproteins. In vivo, Fer kinase assembles into homotrimers via conserved coiled-coil domains. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor exposure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK complexes containing p85. It is expressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be expressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression.
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