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Product > Antibody > AMACR Monoclonal Antibody
AMACR Monoclonal Antibody
AMACR Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 2A10F3
Host: Mouse
Reactivity:Human, Mouse
Applications: WB,IHC,ICC
Product Summary
Size:
50μL
Clonality: 2A10F3
Host: Mouse
Reactivity: Human,Mouse
Applications: WB,IHC,ICC
Product overview
Code
BT-MCA3651
Host
Mouse
Isotype
Mouse IgG2b
Size
50μL
Clonality
2A10F3
Immunogen
Purified recombinant fragment of human AMACR expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
AMACR (alpha-methylacyl-CoA racemase) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in prostatic adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. AMACR can be used as a positive marker for PIN. Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4); also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.
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