Code
BT-MCA2112
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
6B4B5
Immunogen
Purified recombinant fragment of IKBKE (aa1-257) expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon.The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degra-dation of IkB. IkB kinase a(IKKa), previously designated CHUK, interacts with IkB-aand specifically phosphorylates IkB-aon the sites that trigger its degradation, serines 32 and 36. The functional IKK complex contains three subunits, IKKa, IKKb and IKKg(also designated NEMO), and each appear to make essential contributions to IkB phosphorylation. IKK-i is a serine/threonine kinase that shares homology with IKKa and IKKb. IKK-i is pri-marily expressed in immune cells and is induced by lipopolysaccharide and by proinflammatory cytokines including TNFA, IL-1 and IL-6. Overexpression of IKK-i was shown to result in phosphorylation of IkBaon Ser32 and Ser36, and in NFkB activation, suggesting that IKK-i may act as an IkB kinase in the immune system.
Uniprot accession
Gene ID
9641
Synonyms
IKBKE
Research area
Signal transduction,Cell biology,Cardiovascular,Cancer,Immunology
Target protein
IKBKE
