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Product > Antibody > BLK Monoclonal Antibody
BLK Monoclonal Antibody
BLK Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 9D10D1
Host: Mouse
Reactivity:Human
Applications: IHC
Product Summary
Size:
50μL
Clonality: 9D10D1
Host: Mouse
Reactivity: Human
Applications: IHC
Product overview
Code
BT-MCA2209
Host
Mouse
Isotype
Mouse IgG2a
Size
50μL
Clonality
9D10D1
Immunogen
Purified recombinant fragment of BLK expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56KDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.
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