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Product > Antibody > Tyk2 Monoclonal Antibody
Tyk2 Monoclonal Antibody
Tyk2 Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 8G8B3
Host: Mouse
Reactivity:Human
Applications:
Product Summary
Size:
50μL
Clonality: 8G8B3
Host: Mouse
Reactivity: Human
Applications:
Product overview
Code
BT-MCA2927
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
8G8B3
Immunogen
Purified recombinant fragment of Tyk2 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.
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