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Product > Antibody > BRAF Monoclonal Antibody
BRAF Monoclonal Antibody
BRAF Monoclonal Antibody
Product Summary
Size:
50μL
Clonality: 1H12F1
Host: Mouse
Reactivity:Human
Applications: IHC
Product Summary
Size:
50μL
Clonality: 1H12F1
Host: Mouse
Reactivity: Human
Applications: IHC
Product overview
Code
BT-MCA3896
Host
Mouse
Isotype
Mouse IgG1
Size
50μL
Clonality
1H12F1
Immunogen
Purified recombinant fragment of BRAF expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
BRAF(V-raf murine sarcoma viral oncogene homolog B1 ) is the main effectors recruited by GTP-bound Ras to activate the MEK-MAP kinase pathway. B-Raf contains three consensus Akt phosphorylationsites (Ser364, Ser428, and Thr439).B-Raf is a key regulatory molecule of the mitogen-activated protein kinase kinase (MEK),it has a long amino-terminal region,the region is essential for homo-dimerization of B-Raf and hetero-dimerization of B-Raf and c-Raf at the plasma membrane, followed by phosphorylation of Thr118 in the amino-terminal B-Raf-specific region. Notably, in calcium ionophore-stimulated HeLa cells, B-Raf could propagate signals to MEK under the basal level of GTP-Ras. Expression of Raf-B is highly restricted with highestlevels in the cerebrum and testes and defects in braf are involved in a wide range of cancers.The BRAF gene mutation is frequently detected in papillary thyroid carcinoma,melanocytic nevi,primary cutaneous melanomas and colorectal cancers.
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